Encapsulated and immobilized antimicrobial peptides

Antimicrobial peptides (AMPs) are produced by all complex organisms as well as some microbes as part of innate immune response, and display diverse and complex antimicrobial activities against a broad range of Gram negative and Gram positive bacteria, including those resistant to established antibiotic drug therapies, mycobacteria, enveloped viruses, parasites and fungi.  They have gained increasing popularity as a possible alternative to antibiotics due to their broad spectrum activity, low toxicity and most importantly their low tendency to induce antimicrobial resistance (AMR).  The covalent immobilization or encapsulation of these AMPs has the potential to improve efficacy and localized availability.  We are developing nanodelivery vehicles of these AMPs for the treatment of surgical site infections.